Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Calculated molecular weight
16 kDa
Purification method
Affinity Purification
Conjugate
Un-conjugated
Clonality
Polyclonal
Host species
Rabbit
Modification
Phospho-Alpha-synuclein (Tyr125)
Observed molecular weight
14 kDa
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Tyr125 of human Alpha-synuclein
Alias
PD1; NACP; PARK1; PARK4
Cat Number: DPA05390
Phospho-Alpha-synuclein (Tyr125) Rabbit pAb
Applications:
ICC/IFWB
Species Reactivity:
Human
$ 169
/ 50ul
In Stock
50ul100ul
Description
Recommended Dilution
Product Features
Applications
ICC/IFWB
Uniprot
P37840
GeneID
6622
Isotype
IgG
Species Reactivity
Human
Background
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Calculated molecular weight
16 kDa
Purification method
Affinity Purification
Conjugate
Un-conjugated
Clonality
Polyclonal
Host species
Rabbit
Modification
Phospho-Alpha-synuclein (Tyr125)
Observed molecular weight
14 kDa
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Tyr125 of human Alpha-synuclein