This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and transverse tubule. Mutations in this gene are associated with malignant hyperthermia susceptibility, central core disease, and minicore myopathy with external ophthalmoplegia. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Calculated molecular weight
565 kDa
MW
565 kDa
Purification method
Affinity Purification
Conjugate
Un-conjugated
Clonality
Polyclonal
Host species
Rabbit
Immunogen
A synthetic peptide of human Ryanodine Receptor
Alias
CCO; MHS; RYR; MHS1; RYDR; SKRR; RYR-1; PPP1R137
Cat Number: DPA03519
Ryanodine Receptor Rabbit pAb
Applications:
IHCWB
Species Reactivity:
HumanMouseRat
$ 169
/ 50ul
In Stock
50ul100ul
Description
Recommended Dilution
Product Features
Applications
IHCWB
Species Reactivity
HumanMouseRat
Uniprot
P21817
GeneID
6261
Isotype
IgG
Background
This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and transverse tubule. Mutations in this gene are associated with malignant hyperthermia susceptibility, central core disease, and minicore myopathy with external ophthalmoplegia. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]